Compare every Methylfolate product across UK retailers on Suppio, ranked by true value - price per active dose, not pack size. Prices refreshed daily.
Active form of folate requiring no MTHFR enzyme conversion
We rank Methylfolate by price per 200mcg - not by pack size - so a bigger tub with a worse price per dose can't outrank a smaller one that's actually cheaper.
Methylfolate is the active form of folate, which is a B vitamin. Unlike other versions of this vitamin, it does not need to be converted by the MTHFR enzyme (a specific protein in the body that changes folate into a usable form) before the body can use it.
It is used to provide the body with folate that is immediately ready for use. This is particularly helpful for people who have a genetic variation that makes their MTHFR enzyme less effective, meaning they cannot easily process standard folic acid.
To create this supplement, manufacturers start with folic acid and put it through a series of chemical reactions. These steps mimic the body's natural process to strip away certain molecules and add a methyl group, turning the inactive vitamin into the active methylfolate powder used in capsules.
This ingredient is generally mid-range in price. This is because the multi-step chemical process required to convert standard folic acid into the active form is more complex and expensive than producing basic folate.
| Purpose | Typical studied dose | Evidence |
|---|---|---|
| Major depressive disorder (adjunctive therapy with SSRIs or antidepressants) | 15 mg daily | emerging |
Suppio matches identical products across UK retailers by barcode, then ranks by price per active dose rather than sticker price. Value rankings only ever include listings Suppio has independently verified against the live retailer page - unverified data is shown on each product’s own page but excluded from ranking.
Prices across our retailer network are refreshed at least daily.
Active form of folate requiring no MTHFR enzyme conversion
We rank Methylfolate by price per 200mcg - not by pack size - so a bigger tub with a worse price per dose can't outrank a smaller one that's actually cheaper.
Suppio matches identical products across UK retailers by barcode, then ranks by price per active dose rather than sticker price. Value rankings only ever include listings Suppio has independently verified against the live retailer page - unverified data is shown on each product’s own page but excluded from ranking.
Prices across our retailer network are refreshed at least daily.